Yes, it is possible to get infected with HMPV more than once. Reinfections are usually milder than the first infection because the immune system has been exposed to the virus before.
The Ministry of Health and Population stated that the Human Metapneumovirus (HMPV) spreading in China is a common virus, and there is no need to panic.
Immune Responses to HMPV
When a person gets infected with HMPV for the first time, the immune system makes antibodies to fight the virus. These antibodies can help protect against future infections, but it's still possible to get infected again.
Preventive Measures

As of January 27, 2025, there is no vaccine for HMPV, but following preventions can reduce the risk of infection:
- Good Hygiene: Regular handwashing, covering coughs and sneezes, and avoiding close contact with infected individuals can help prevent the spread of the virus.
- Avoiding Crowded Places: Avoiding crowded indoor places can help reduce the risk of contracting hMPV or other respiratory infections.
- Boosting Immunity: A balanced diet, regular exercise, and proper rest helps to increase immune system to fight against infections.

Conclusion
While it is possible to get infected with human metapneumovirus twice. Reinfections are less severe than the initial illness due to the previous exposure to the virus. Individuals with weak immune systems or serious health conditions should take extra precautions. Preventive measures, such as good hygiene and boosting immunity are essential to reduce the risk of this virus.